See also: List of ineffective
cancer treatments
The production of the
hormone melatonin, a sleep regulator, is inhibited by light and permitted by
darkness as registered by photosensitive ganglion cells in
the retina. To some degree, the reverse is true forserotonin[citation needed],
which has been linked to mood disorders. Hence, for the purpose of manipulating melaton in levels
or timing, light boxes providing
very specific types of artificial illumination to
the retina of the eye are effective.[citation needed]
Light therapy uses either
a light box which emits up to 10,000 lux of
light at a specified distance, much brighter than a customary lamp, or a lower
intensity of specific wavelengths of light from the blue (460 nm)
to the green (525 nm) areas of the visible spectrum.[39] A
1995 study showed that green light therapy at doses of 350 lux produces
melatonin suppression and phase shifts equivalent to 10,000 lux white light
therapy,[40][41] but
another study published in May 2010 suggests that the blue light often used for
SAD treatment should perhaps be replaced by green or white illumination,
because of a possible involvement of the cones in
melatonin suppression.[42]
In treatment, the
patient's eyes are to be at a prescribed distance from the light source with
the light striking the (lower) retina. This does not require looking directly
into the light.
Considering three major
factors – clinical efficacy, ocular and dermatologic safety, and visual
comfort, the Center for Environmental Therapeutics (CET) recommends the
following criteria for light box selection:[43]
·
Light boxes should have been
tested successfully in peer-reviewed clinical trials.
·
The box should provide 10,000
LUX of illumination at a comfortable sitting distance. Product specifications
are often missing or unverified; illuminance can be controlled using a light
meter.
·
Fluorescent lamps should have a
smooth diffusing screen that filters out ultraviolet (UV) rays. UV rays are
harmful to the eyes and skin.
·
Blue light is known to be
superior to red light in managing depressive symptoms which have a seasonal
pattern.[44]
·
The light should be projected
downward toward the eyes at an angle to minimize aversive visual glare.
·
Smaller is not better; when
using a compact light box, even small head movements will take the eyes out of
the therapeutic range of the light.
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